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Interface Biologics Announces Spinout, Ripple Therapeutics

,p.TORONTO, Canada, January 14, 2020 – Following the sale of its surface modification business to Evonik (EVR:ETK), Interface Biologics Inc. (“IBI”), is pleased to announce the launch of Ripple Therapeutics Corporation (“Ripple”), a privately held, clinical stage developer of novel drugs.

The Ripple Epidel ® technology is founded on a discovery that drugs can be engineered into controlled release Pharmaceuticals and Medical Device Coatings without the use of polymers or excipients.  The proprietary prodrugs are new chemical entities (NCEs) that have unique properties that allow them to be processed into standalone drug delivery implants (e.g. intravitreal implants and micro/nanoparticles) or as coatings on medical devices. The implants and coatings undergo surface erosion to give zero order drug release profiles and are highly engineerable (e.g. different forms, shapes, and sizes) to tailor drug dose and duration for the specific indication of interest. The flexibility in molecular design results in drug doses that are within the therapeutic window, delivering the right amount of drug for the right amount of time. This has the potential to improve patient safety and clinical outcomes.

Ripple’s lead product, IBE-814 IVT, is a fully degradable intravitreal dexamethasone prodrug implant that targets diabetic macular edema and retinal vein occlusion.  IBE-814 is designed to deliver a low, consistent, efficacious dose for six to nine months which is significantly longer than the leading commercial product.  With ~1/10th the drug loading, there is also the potential of reducing the steroid-related adverse events that affect the current commercial products.  The FDA has confirmed an abbreviated regulatory path via 505(b)(2) and the company is planning to initiate its Phase II clinical trial in Australia in the second half of 2020.

“Following the successful sale of our surface modification business to Evonik, we felt that the best way to capitalize on our Epidel technology was to create a new company – Ripple Therapeutics – in order to facilitate incremental investment,” stated Tom Reeves, President & CEO of Interface Biologics and Ripple Therapeutics. “IBI will continue to focus on its licensing agreement with Fresenius Medical Care and to develop its drug coated balloon program using the Kinesyx platform. The majority of former IBI management and employees will transition to Ripple Therapeutics.  Ripple’s initial focus is in ophthalmology, but this technology platform has wide ranging capabilities for sustained local drug delivery across a variety of drug classes and therapeutic areas.  We are actively pursuing a $25M Series A financing which will allow us to take our lead product, IBE-814 IVT, through a Phase II clinical trial as well as to continue to develop the technology platform and other product applications.”

About Interface Biologics:

Interface Biologics (IBI) is an early commercial stage privately held company that develops innovative materials for Medtech applications. IBI surface modification additives are used in FDA- approved medical devices and are clinically proven to reduce infection and thrombus-related complications.     www.interfacebiologics.com

About Ripple Therapeutics:

Ripple Therapeutics Corporation is an early clinical stage privately held company that develops novel drugs. Ripple’s EpidelÒ technology is founded on a discovery that drugs can be engineered into controlled release Pharmaceuticals and Medical Device Coatings without the use of polymers or excipients.  The proprietary prodrugs are new chemical entities (NCEs) that have unique properties that allow them to be processed into standalone drug delivery implants or as coatings on medical devices. www.rippletherapeutics.com

Media Contact:

Julie Fotheringham, Partner, Hageman Communications

M: 416-951-7988 E: Julie.fotheringham@hageman.ca

20 Mar, 2023
Lisbon, March 20, 2023, Hovione, the specialist integrated CDMO, leader in spray drying and particle engineering, and Ripple Therapeutics, a leading ophthalmic sustained drug delivery company, have entered a strategic partnership to expand the use of Ripple's Epidel® platform beyond ophthalmic applications. The core feature of Ripple’s Epidel® technology is the ability to deliver sustained-release pharmaceuticals with surface erosion release kinetics without the use of polymers or excipients. This enables higher drug loading, smaller size implants, defined and predictable biocompatible degradation products with straightforward and scalable manufacturing processes. Surface erosion-based drug release provides a highly effective way to control dose and duration. By incorporating Ripple's Epidel® platform into its toolbox, Hovione can expand its portfolio of novel drug delivery solutions to the pharmaceutical industry. “The combination of technology synergy, innovative vision and cultural fit makes collaborating with Hovione an exciting next step in the advancement of the Epidel® platform beyond the ophthalmic field,” stated Dr. Wendy Naimark, Ripple co-founder and Chief Technology Officer. “Hovione’s expertise in controlled, sustained drug delivery, along with their experience in chemical synthesis and pharmaceutical manufacturing, makes for a great partnership.” "We are thrilled to partner with Ripple, who developed a state-of-the-art platform for sustained release," says Dr. Jean-Luc Herbeaux, Hovione's CEO. " Our shared goal is to accelerate and broaden the access to this highly innovative and enabling technology for the benefit of our pharmaceutical customers and their patients worldwide." By extending the use of the Epidel® platform beyond ocular applications, this partnership will enable the development of a diverse range of new products with optimal sustained release profiles. About Hovione: Hovione is an international company with over 60 years of experience in pharmaceutical development and manufacturing operations. As a Contract Development and Manufacturing Organization (CDMO) with a fully integrated offering of services for drug substances, drug product intermediates and drug products. The company has four FDA inspected sites in the USA, Portugal, Ireland and China and development laboratories in Lisbon, Portugal and New Jersey, USA. Hovione provides pharmaceutical customers services for the development and compliant manufacture of innovative drugs, including highly potent compounds, and customized product solutions across the entire drug life cycle. In the inhalation area, Hovione offers a complete range of services, from API, formulation development and devices. Hovione's culture is based on innovation, quality and dependability. Hovione was the first Chemical/ Pharmaceutical Company to become a Certified B Corp, is a member of Rx-360, EFCG and participates actively in industry quality improvement initiatives to lead new global industry standards. About Ripple Therapeutics: Ripple Therapeutics Corporation is a clinical stage, privately held company that is focused on ophthalmic therapeutics with controllable, sustainable drug delivery. The core feature of Ripple’s Epidel™ technology is the ability to engineer sustained-release pharmaceuticals with surface erosion release kinetics without the use of polymers or excipients. Ripple’s novel therapeutics provide for better outcomes for patients, easier management of care for physicians and lower costs for payors. Ripple has a full product pipeline in development. www.rippletherapeutics.com For more information, please visit www .hovione.com or contact: Vanessa Romeu | Communications Director | vromeu@hovione.com |Tel: +351 21 982 9000 Or visit www.rippletherapeutics.com or contact: Julie Fotheringham | V.P. Marketing, People & Culture | 416-951-7988| jfotheringham@rippletherapeutics.com
25 Jan, 2023
TORONTO, ON, CANADA / JANUARY 24, 2023 - Ripple Therapeutics is proud to announce that our organization has been named on the 2023 Best Workplaces for Start-ups. Ripple received this honour after a thorough and independent analysis conducted by Great Place to Work®. The list is based on direct feedback from employees of the hundreds of organizations that were surveyed by Great Place to Work®. To be eligible for this list, organizations must be Great Place to Work- Certified™ and have exceptionally high scores from employees on the Trust Index survey. “At Ripple, we are intentional about investing in people”, commented Tom Reeves, President & CEO. “Our core values emphasize that we care, we collaborate, and we have fun while persevering to find innovative solutions to complex problems. As such, it’s great to receive this independent third-party validation that we are a great place to work.” About Ripple Therapeutics Ripple Therapeutics Corporation is a clinical stage, privately held company that is focused on ophthalmic therapeutics with controllable, sustainable drug delivery. The core feature of Ripple’s Epidel™ technology is the ability to engineer sustained-release pharmaceuticals with zero-order release kinetics without the use of polymers or excipients. Ripple has a full product pipeline in development. www.rippletherapeutics.com About Great Place to Work® Great Place to Work is the global authority on high-trust, high-performance workplace cultures. Through proprietary assessment tools, advisory services, and certification programs, Great Place to Work recognizes Canada’s Best Workplaces in a series of national lists including those published by The Globe & Mail (Canada) and Fortune magazine (USA). Great Place to Work provides the benchmarks, framework, and expertise needed to create, sustain, and recognize outstanding workplace cultures. Visit us at www.greatplacetowork.ca or find us on Twitter at @GPTW_Canada. Media Contact Julie Fotheringham, V.P. Marketing, People & Culture M: 416-951-7988 E: jfotheringham@rippletherapeutics.com
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